Statistical Analysis Stack Exchange
Statistical Analysis Stack Exchange

Questions tagged [systematic-review]

The process of collecting already existing studies in a reproducible systematic way. If your question is about the statistical analysis of studies which have been collected in this way consider using the meta-analysis tag as well or instead.

Collecting scientific studies for subsequent processing includes: question definition, search term definition, conducting the search, extracting data from the primary studies, assessing the risk of bias of the studies. The term systematic review is sometimes used to encompass meta-analysis but many authors keep them separate and refer to systematic review with meta-analysis.

The Wikipedia article on systematic review provides a longer account of the process and links to material.

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Is there any meaningfully robust approach to conduct a network meta-analysis of diagnostic test accuracy studies?

Background: I am working on a systematic review including several imaging modalities for coronary artery disease, but the evidence network is quite large, including different modalities, often compared one to the other in an ample network. Network…
Giuseppe Biondi-Zoccai
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Analysing non-outcome variables in meta-analysis

I am working on a meta-analysis project in suicidology. This is more like an academic exercise and will not necessarily be submitted for publication, but I try to be as rigorous as possible. Now here is my question: am I allowed to analyse data that…
user47679
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Which is the best method for network meta-regression?

Network meta-analysis (i.e. mixed treatment comparison) is becoming more and more important in evidence synthesis. An interesting aspect of this type of meta-analysis is the possibility to explore the impact of moderators/effect modifiers in a…
Giuseppe Biondi-Zoccai
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Pooling in a Meta Analysis

I am looking to pool data for adverse events for a meta analysis and I wanted to see if my plan made sense I want to pool my AE together based on the Clavien Dindo categorizations, as this will make the most sense clinically. I am running into the…
Vicki Archer
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Converting zero count regression model back to frequency data?

I’m new to statistics but I’m performing a systematic review into exercise and alcohol intake. One of the papers uses a zero inflated count regression model to report the alcohol consumption per day. Is there a way to convert this back to frequency…
JoshuaDosh
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Should I be running a meta-analysis?

I am working on a project that assesses the slope of the species area curve across multiple studies (right now I have 35 studies). I have slope values for all these studies and all of these slopes were generated from the same model structure. I do…
Leo Ohyama
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Fisher's method for combining p-values

I'm using the sumlog function in the metap package of R, and have a few questions about the nuts-and-bolts of this function: 1)Some of my p-values are reported as '<0.001'. How do I include these? use 0.001? 2)A few studies in my review don't give…
Keno
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Can one perform a meta analysis on solely the results of a study, without the use of raw data?

If not, since a systematic review would be the next option, are there any analyses you can conduct on the results of the studies that one intends to analyze
RandomVector12
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How to combine observational studies

I am trying to show the releationship between a drug and an outcome in a particular setting. Using a systematic review, I have found 18 studies addressing this topic. Among those, the highest quality evidence comes from observational studies (n=130)…
mankowitz
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Is it appropriate to pool incidence data from a systematic review for a summary RR?

I have a systematic review to compare incidence of an illness (Y) with or without an intervention (so groups A and B). These groups are relatively homogeneous, so aside from unmeasured confounders I think it is a reasonable (enough) assumption to…
stensy
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Comparing pooled complication rates

I have started a meta analysis comparing the complication rates of different treatments of distal radius fractures. I have pooled the complication rates (n/N) for each treatment separately using the inverse variance method, the DerSimonian-Laird…
Rotterdam
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Fields of application of meta-analysis

Systematic reviews and meta-analyses have been used extensively in many fields and for many years. For instance, there are exceedingly numerous examples of systematic reviews and meta-analyses in medicine, psychology, physics, economics, and…
Giuseppe Biondi-Zoccai
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Pool data for systematic review

I am new to this website and to statistics as well. Currently I am writing a systematic review on complications and reoperations after distal radius fractures(Systematic review on the comparison of complications and reoperations after plaster…
Rotterdam
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How to calculate a new mean from different means for my Systematic Review and how to calculate a new SD?

I am currently doing a systematic review on distal radius fractures. I want to give a mean age and sd in my systematic review. Therefor I need to calculate the mean from all the different means of the added studies. Study 1: Included patients 30,…
John Johnson
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Scientific meta analysis

I will be analysing the effects of enzyme inhibitors on a certain enzyme on invivo and invitro animal and human cancer cell model lines as this enzyme is associated with pathogenicity; to assess whether targeting this enzyme with inhibitors can be a…
Jay
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