Questions tagged [relative-risk]

The relative risk (also called 'risk ratio') is the quotient of the probabilities of an event under two conditions (ie, p1/p2). The RR has a possible range of [0, +infinity). It is a common measure of effect size in biomedical research.

The relative risk (also called 'risk ratio') is the quotient of the probabilities of an event under two conditions (i.e., $p_1/p_2$). The RR has a possible range of $[0, +\infty)$. It is a common measure of effect size in biomedical research.

In a typical study with two categories (say, treatments), and two outcomes (say, relapse or not), the data can be represented by a 2x2 table:

            outcome1   outcome2 
treatment1      a         b  
treatment2      c         d  

The relative-risk is estimated by:
$$ \text{RR}=\frac{\frac{a}{a+b}}{\frac{c}{c+d}} $$ Note that the RR is not symmetrical: when the outcome is unrelated to the treatment, RR = 1, when outcome1 is more likely given treatment1 than treatment2, RR > 1, but when it is less likely, RR < 1. Moreover, as outcome1 is increasingly more likely with treatment1, RR goes on infinitely, but as outcome1 becomes less likely, RR 'only' goes to 0. In addition, note that the relative risk between two treatments with a fixed difference diminishes as the the base rate increases. That is, when the probabilities are 2% and 1%, RR = 2, but when they are 99% and 98%, RR = 1.01. For this reason, the less frequent of the two outcomes is often used as 'outcome1' when calculating the RR.

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Poisson regression to estimate relative risk for binary outcomes

Brief Summary Why is it more common for logistic regression (with odds ratios) to be used in cohort studies with binary outcomes, as opposed to Poisson regression (with relative risks)? Background Undergraduate and graduate statistics and…
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Which statistical model is being used in the Pfizer study design for vaccine efficacy?

I know there's a similar question here: How to calculate 95% CI of vaccine with 90% efficacy? but it doesn't have an answer, at the moment. Also, my question is different: the other question asks how to compute VE, using functions from a R package.…
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How exactly is the "effectiveness" in the Moderna and Pfizer vaccine trials estimated?

As in the title. Is this "a risk ratio"? How is it calculated, if you could provide an example with numbers for both trials, please? I am not a statistician, but I am familiar with the binomial distribution - I suppose it is used here to calculate…
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How to interpret the output of predict.coxph?

After fitting a coxmodel it is possible to make predictions and retrieve the relative risk of new data. What I don't understand is how the relative risk is computed for an individual and what is it relative to (i.e. the average of the population)?…
user4673
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How do you explain the difference between relative risk and absolute risk?

The other day I had a consultation with an epidemiologist. She is an MD with a public health degree in epidemiology and has a lot of statistical savvy. She mentors her research fellows and residents and helps them with statistical issues. She…
Michael R. Chernick
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Calculating risk ratio using odds ratio from logistic regression coefficient

I have a binary logistic regression with just one binary fixed factor predictor. The reason I don't do it as a Chi square or Fisher's exact test is that I also have a number of random factors (there are multiple data points per individual and…
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Prerequisite for conversion from odds ratio to relative risk to be valid

as question, since we can do the conversion from odds ratio (p1/q1)/(p2/q2) to relative risk (p1/(p1+q1))/(p2/(p2+q2)) fairly easily, I wonder if there is anything that I need to pay attention before doing this? It is obvious that if I am doing a…
lokheart
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Meta analysis on studies with 0-frequency cells

I am familiar with meta analysis and meta regression techniques (using the R package metafor from Viechtbauer), but I recently stumbled on a problem I can't easily solve. Say we have a disease that can go from mother to the unborn child, and it has…
Joris Meys
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Assess temporary effect of treatment

Imagine that I have a treatment that reduces the likelihood of response to a stimulus. This could be anything you like, but the simplest example is of a treatment (e.g., hand washing, mask wearing, etc.) that prevents disease when exposed. For…
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Estimating adjusted risk ratios in binary data using Poisson regression

I am interested in estimating an adjusted risk ratio, analogous to how one estimates an adjusted odds ratio using logistic regression. Some literature (e.g., this) indicates that using Poisson regression with Huber-White standard errors is a…
user49291
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Calculation of Relative Risk Confidence Interval

I am using the epitools in R for calculating the confidence interval of relative risk. http://bm2.genes.nig.ac.jp/RGM2/R_current/library/epitools/man/riskratio.html There are three methods inside for calculations: namely Wald, Small and Boot. I want…
lokheart
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Why is relative risk not valid in case control studies?

I'm getting my information from: http://sphweb.bumc.bu.edu/otlt/mph-modules/ep/ep713_analyticoverview/EP713_AnalyticOverview5.html It says that in a case-control study, you can not compute the probability of disease in each exposure group because…
Plumpie
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How to calculate the relative risk based on two independent confidence intervals

Medicine A cures 30% of patients (95% CI: 17 to 45). Medicine B cures 15% of patients (95% CI: 10 to 20). So I can divide 30% by 15% and say that medicine A is twice as likely to cure the patients compared to medicine B, right? My question is: how…
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How to calculate the "exact confidence interval" for relative risk?

I am working on some MRSA data and need to calculate the relative risk of a group of hospitals compared with the remaining hospital. My colleagues throws me an excel with a formula inside to calculate the "exact confidence interval of relative…
lokheart
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Comparing relative risks of independent samples

I would be really grateful for help with the following. I have two independent studies looking at treatment A on disease B. Both give RRs of disease B according to treatment exposure for different age groups (<50 and >50). Below is a hypothetical…
John
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