Questions tagged [double-blind]

A double blind study is one in which neither the researchers nor the subjects know which treatment or condition is given to which subject.

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In the specific context of baseline traits of study participants (see ref.), what is p value? What's being tested and is it pointless? meaningful?

(If answering, please assume readers already have a basic understanding of what p is in general.) The is it pointless part of this question seems to be YES; that part of the question is similar to, and I'd guess answered by the answers to…
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Can I reuse the dataset set aside for performing t-test based on the following condition?

I have a small number of samples and large number features. For doing the feature selection I'm going to divide my total set into a feature selection set and a test set.I run the t-test on the former and I test on the latter. Now my question is,…
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A randomized, double-blind crossover (AB/BA) observational study of new use of an FDA approved drug

I found a new use of a drug already in use. The results are as follows. Serail No. of Patient-- Attacks while on Placebo-- Attacks while on drug --Difference in the no. of attacks 1- 23- 2- 21 2- 17- 1- 16 3- 13- 3- 10 4- 26- 0- 26 5-…
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Effect of random samples on multiple groups in double-blind study

I have four different groups of analysts, each of which was given a random sample from a pool of possible images to classify in an online double-blind study. These analyst groups were created after the blind study based on their answers on a set of…
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In a stratified RCT, should strata be combined if a too small sample size is attained in randomization?

My question refers to a situation where the number of participants in some strata is unexpectedly low. Should randomization proceed in the same way as declared in the Protocol, i.e. by performing randomizing independently in each strata, or should…
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How to specify a risk model?

I'm reading this article. The authors indicated that for a random sample of 12 characteristics and 3600 patients affected in two arms (control and treatment arm), they fitted a risk model consisting of all 12 characteristics in the patients in the…
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Design of a triangular test (or 2-out-of-5) when there is intra-group variability of samples

I would like to submit to an expert group a set of images from two genetically different types of plants to see if they can find a difference. I have 20 images for each of the two types. Images are images of cells that are so specific that only a…