Statistical Analysis Stack Exchange
Statistical Analysis Stack Exchange

Questions tagged [crossover-study]

A crossover study is an experiment in which subjects are given a series of treatments in succession. Ideally, all orderings of treatments are used with equal numbers of subjects. Crossover studies are common in clinical trials. Carryover effects are a special concern with this design.

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How to display error bars for cross-over (paired) experiments

The following scenario has become the Most-FAQ in the trio of investigator (I), reviewer/editor (R, not related to CRAN) and me (M) as plot creator. We can assume that (R) is the typical medical big boss reviewer, who only knows that each plot must…
Dieter Menne
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R: Post-hoc test on lmer. emmeans and multcomp packages

I'm working on a dataset of 2x2 crossover study. I have 10 subjects, each of them underwent both A and B treatment but in a different sequence. (This is a balanced study.) I want to see how A and B treatments improve lipid levels. My thought…
Daisy Chang
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Pre-post treatment comparison crossover study 2 treatments 2 baselines

I would like to analyse data with a crossover design. Each subject was assigned to a sequence (AB or BA), i.e. 2 periods. Each period consisted of one measurement before treatment (baseline or pre-treatment) and one after treatment. The data look…
Ruben
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How to handle crossed and nested terms in a crossover design

Here comes my case: I conducted an experiment with the following design: 30 participants, each with a unique id, were screened and classified according to a trait. Then, all participants were tested in two conditions (in random order), and each…
rcirer
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What is the meaning of the beta-coefficient for an interaction term in a crossover study?

I have asked a similar question here: stackoverflow I am puzzled by the interpretation for an interaction term. In my data my Y is an interval variable with the health outcome of an experiment. I have used an interaction term in which I have…
Pulse
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stepped wedge and additive intervention effects

Let's say we want to randomize 400 caregivers to a parenting intervention or a wait-list control group. But we also want to look at a program variation for a sub-sample of caregivers of children with identified conduct problems (e.g., a more intense…
Eric Green
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Analysis of a cluster crossover design

I am analyzing data from a cluster randomized cross over trial. There are 9 clusters and 3 periods in the data. The clusters are dental clinics and in each period different patients are sampled. I have three interventions (control, treatment1,…
Jonathan Marin
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How to analyze ordinal repeated measures data

I have data from an ordinal scale, with the score ranging from 1-4. Each subject has 9 assessments on this scale (study is a 9-way crossover design), and there are no missing data. What is the proper statistical analysis for ordinal data that also…
Bosley
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2x2 Crossover Trial - minimum observations to run a linear mixed model

I am planning a 2x2 randomized crossover trial with about 20-25 subjects. There will be one measurement (continuous outcome) with period A (intervention) and period B (placebo) for each individual. There will be a sufficient washout period and I…
mdx
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What statistical analysis is most appropriate for a cross-over treatment design? How many participants?

I am asking on behalf of a colleague. I was hoping to have an answer for him, but I rather seek some guidance and be a bit more confident. He is designing a treatment study, which I am inventing here for illustrative purposes. The treatment…
Behacad
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Mixed model for multiple measurements in a crossover study (SAS)

I am currently trying to analyse data from a crossover study. In brief, the study is of a crossover design, where each participant takes part in 2 separate sessions, where they play a game. This game repeatedly measures a few different variables,…
Daniel Hovey
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McNemar test comparing two proportions in a crossover trial

In a crossover trial involving 50 patients, two dialysis treatment schedules were compared.Ten patients complained of vomiting on both schedules, 30 on neither, nine on treatment A only and one on treatment B. (a) What are the proportions of…
Art
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ANCOVA for 2X2 crossover with baseline measurements - validity of assumptions

I'm trying to learn how to do ANCOVA for a 2x2 crossover study with baseline measurements. I have followed the analysis performed at Mehrotra 2014 "A recommended analysis for 2 x 2 crossover trials with baseline measurements" (The article is…
Korem
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four period crossover design in lmer or lme4

Our experimental setting is a four-period crossover design: the table below indicates typical types of experimental data. Subj Treat Period Seq AUClast A01 R 1 A 356 A01 R 3 A 565 A01 T 2 A 596 A01 T 4 …
Ji Jin Lee
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What is this design and how can I analyze it?

| Time=1 | Time=2 | Time=3 | Time=4 …
ved
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