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Questions tagged [mendelianrandomization]

Mendelian randomization is a method of using measured variation in genes of known function to examine the causal effect of a modifiable exposure on disease in observational studies.

In epidemiology, Mendelian randomization is a method of using measured variation in genes of known function to examine the causal effect of a modifiable exposure on disease in observational studies. The design has a powerful control for reverse causation and confounding, which often impede or mislead epidemiological studies.

Source: Wikipedia.

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Instrumental variables with interactions between endogenous variables

I have two endogenous variables $x_1$ and $x_2$ and am trying to estimate the following model: $$y = \theta_0 + \theta_1 x_1 + \theta_2 x_2 + \theta_{12} x_{12}$$ where $x_{12} = x_1\times x_2$. I'm particularly interested in the interaction term…
Biblot
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Mendelian Randomization (MR) prove there is a causal effect of X on Y

All the time, I have believed that MR analysis can provide the information such as "there is a causal effect of X on Y", until I saw a statement on this paper (https://www.nature.com/articles/s41588-020-0631-4): A low P value from CAUSE (or any MR…
Amy Chang
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Instrument variables in Mendelian Randomization (MR)

As I know, in Mendelian Randomization (MR) analysis, many researchers will select SNPs which are correlated with exposure X (or Risk Factor) as Instrument Variables (IVs), but not all of these SNPs are correlated with outcome Y (Sometimes, all SNPs…
Amy Chang
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