I have paired data pre and post-exposure to a drug. I would like to calculate the percentage change of my metric in response to the drug. I am getting a little confused and I am probably overthinking it. I think I should calculate the change per patient then the average of the individual changes to get the overall change. I would like to go on to see if the calculate p-values for the change.
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Yes. You are probably overthinking it, although there could be some subtleties
Average percent change: Calculate the percent change for each individual, then average the results. This is probably what you are looking for
Percent change of the average: Calculate the "before" and "after" averages, then get the percent change.
David
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