I want to build a single linear model that is based on these independent stores and their corresponding time series.
Is this mixed modeling? If I do a loop I’ll just get 100s of different models, one for each store. But I want 1 single model that is fit to all of them.
Mixed-effects modeling is one of the modeling approaches you can employ, which might lend itself better to the data at hand than other paradigms, but in no way we can simply say "this data at hand requires mixed-effects modeling".
Having said that, yes, this paradigm you presented can be tackled by mixed-effects modelling. You didn't state your dependent or independent variables, but basically your hundreds of stores would simply be a group variable for your observations, and then, in simplified terms, you estimate the fixed effect (the overall average effect) and the random effects (deviations in effects due to sampling of a population).
Notice it's important in this paradigm for you to consider the effect in each store unimportant. If you're interested in modeling the stores at hand and perhaps compare their coefficients, then their effects are to be considered fixed-effects.
You can read more about mixed-effects modeling on this site (and I recommend you to do that exactly that, because it can open another can of worms if you don't understand what's happening when applying it) navigating the tag mixed-model:
Also, if you want to build on a correlation structure directly instead of specifying the random effects, give a read on Generalized Least Squares (here's a question of SO comparing gls
and lme
).