Numerically deriving the MLEs of GLMM is difficult and, in practice, I know, we should not use brute force optimization (e.g., using optim in a simple way). But for my own educational purpose, I want to try it to make sure I correctly understand the model (see the code below). I found that I always get inconsistent results from glmer().
In particular, even if I use the MLEs from glmer as initial values, according to the likelihood function I wrote (negloglik), they are not MLEs (opt1$value is smaller than opt2). I think two potential reasons are:
negloglikis not written well so that there is too much numerical error in it, and- the model specification is wrong. For the model specification, the intended model is:
\begin{equation} L=\prod_{i=1}^{n} \left(\int_{-\infty}^{\infty}f(y_i|N,a,b,r_{i})g(r_{i}|s)dr_{i}\right) \end{equation} where $f$ is a binomial pmf and $g$ is a normal pdf. I am trying to estimate $a$, $b$, and $s$. In particular, I want to know if the model specification is wrong, what the correct specification is.
p <- function(x,a,b) exp(a+b*x)/(1+exp(a+b*x))
a <- -4 # fixed effect (intercept)
b <- 1 # fixed effect (slope)
s <- 1.5 # random effect (intercept)
N <- 8
x <- rep(2:6, each=20)
n <- length(x)
id <- 1:n
r <- rnorm(n, 0, s)
y <- rbinom(n, N, prob=p(x,a+r,b))
negloglik <- function(p, x, y, N){
a <- p[1]
b <- p[2]
s <- p[3]
Q <- 100 # Inf does not work well
L_i <- function(r,x,y){
dbinom(y, size=N, prob=p(x, a+r, b))*dnorm(r, 0, s)
}
-sum(log(apply(cbind(y,x), 1, function(x){
integrate(L_i,lower=-Q,upper=Q,x=x[2],y=x[1],rel.tol=1e-14)$value
})))
}
library(lme4)
(model <- glmer(cbind(y,N-y)~x+(1|id),family=binomial))
opt0 <- optim(c(fixef(model), sqrt(VarCorr(model)$id[1])), negloglik,
x=x, y=y, N=N, control=list(reltol=1e-50,maxit=10000))
opt1 <- negloglik(c(fixef(model), sqrt(VarCorr(model)$id[1])), x=x, y=y, N=N)
opt0$value # negative loglikelihood from optim
opt1 # negative loglikelihood using glmer generated parameters
-logLik(model)==opt1 # but these are substantially different...
A simpler example
To reduce the possibility of having large numerical error, I created a simpler example.
y <- c(0, 3)
N <- c(8, 8)
id <- 1:length(y)
negloglik <- function(p, y, N){
a <- p[1]
s <- p[2]
Q <- 100 # Inf does not work well
L_i <- function(r,y){
dbinom(y, size=N, prob=exp(a+r)/(1+exp(a+r)))*dnorm(r,0,s)
}
-sum(log(sapply(y, function(x){
integrate(L_i,lower=-Q, upper=Q, y=x, rel.tol=1e-14)$value
})))
}
library(lme4)
(model <- glmer(cbind(y,N-y)~1+(1|id), family=binomial))
MLE.glmer <- c(fixef(model), sqrt(VarCorr(model)$id[1]))
opt0 <- optim(MLE.glmer, negloglik, y=y, N=N, control=list(reltol=1e-50,maxit=10000))
MLE.optim <- opt0$par
MLE.glmer # MLEs from glmer
MLE.optim # MLEs from optim
L_i <- function(r,y,N,a,s) dbinom(y,size=N,prob=exp(a+r)/(1+exp(a+r)))*dnorm(r,0,s)
L1 <- integrate(L_i,lower=-100, upper=100, y=y[1], N=N[1], a=MLE.glmer[1],
s=MLE.glmer[2], rel.tol=1e-10)$value
L2 <- integrate(L_i, lower=-100, upper=100, y=y[2], N=N[2], a=MLE.glmer[1],
s=MLE.glmer[2], rel.tol=1e-10)$value
(log(L1)+log(L2)) # loglikelihood (manual computation)
logLik(model) # loglikelihood from glmer
