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I have two groups of samples with a proportion of mutations in each sample being a particular type (the proportions are represented as a fraction of 1). How to I check if that type of mutation is significantly likelier to happen in one group over the other?

kjetil b halvorsen
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    You could use a $\chi^2$ test for proportions. –  Sep 07 '13 at 02:09
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    See http://stats.stackexchange.com/questions/2391/what-is-the-relationship-between-a-chi-square-test-and-test-of-equal-proportions?rq=1 – Gala Sep 07 '13 at 05:06
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    If you want to be able to consider both one- and two- tailed tests, what about a two-sample proportions test? – Glen_b Sep 07 '13 at 07:16
  • Possible dups: https://stats.stackexchange.com/questions/286663/chi-square-test-or-z-test-for-comparing-two-proportions, https://stats.stackexchange.com/questions/234010/2-sample-proportions-z-test-vs-fishers-exact-test, https://stats.stackexchange.com/questions/284718/test-for-proportion-difference-vs-test-for-odds-ratios, https://stats.stackexchange.com/questions/2391/what-is-the-relationship-between-a-chi-squared-test-and-test-of-equal-proportion – kjetil b halvorsen Feb 02 '20 at 23:59

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Partially answered in comments:

You could use a χ2 test for proportions. – user25658 If you want to be able to consider both one- and two- tailed tests, what about a two-sample proportions test? – Glen_b

See also What is the relationship between a chi squared test and test of equal proportions?

kjetil b halvorsen
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