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I have experiment leading to repeated measures 4-way ANOVA:

Factors:

  • group: two groups (between)
  • intervention: three interventions (within)
  • timepoint: two measurements, one before and one after intervention (within)
  • an additional condition with 2 factor levels (within)

Since a Four-Way ANOVA is very complicated, I would like to perform a Three-Way ANOVA. However, each factor is of interest, so none should be dropped.

Possibilities:

  • I have read about the possibility of merging two factors. Does anyone have any literature recommendations on this? (see: Can you convert three-way ANOVA to one-way ANOVA?)
  • I was thinking that a change score could be calculated between the measurements before and after the intervention (or measurement-post - measurement-pre). Could I reduce the model with this "Change-Score" by the factor timepoint (pre and post-intervention measurements)? I am not sure if this is an acceptable practice.
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