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Suppose that $X_1$ and $X_2$ are independent. I wonder if $X_1$ and $X_2$ conditioning on $X_1+X_2$ can be independent as well.

If $X_1$ and $X_2$ are normally distributed, then the above statement is wrong. I wonder if the statement can be true for some random variables.

user1292919
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$X_1 ~|~ X_1+X_2$ and $X_2 ~|~ X_1+X_2$ are not independent. They are perfectly negatively correlated distributions.

krkeane
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  • They can be independent - see the other answers. – fblundun Jul 04 '21 at 08:18
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    $X_1 + X_2$ is an instance of a "collider" for $X_1$ and $X_2$. This is discussed in: [Day, Felix R., et al.](https://www.cell.com/ajhg/pdf/S0002-9297(15)00514-5.pdf) "A robust example of collider bias in a genetic association study." The American Journal of Human Genetics 98.2 (2016): 392-393. See also https://en.wikipedia.org/wiki/Collider_(statistics) . – krkeane Jul 06 '21 at 11:51
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It's possible if one of them is constant - for example if $X_1$ has a Bernoulli distribution and $X_2$ is always equal to zero.

fblundun
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