I have a question regarding weighing of data in compartmental modelling.
I have four different compartments between which there are reactions occurring, all of them first order. I have monitored concentrations in these compartments over time, and would like to use these data to estimate rate constants for the reactions between them. Problem is, two of the four compartments always have a large standard deviation between the replicates, largely because the quantification method of the element in those pools is not good.
I was wondering if it would be possible to give some kind of weight to the different compartments, so that the ones that we can measure well are "more important" when fitting than the others.
Many thanks in advance!!!
Charlotte
