(Not really an answer, simply an elaboration on the comment. Apologies in advance.
It is a very interesting question. Hopefully the comment will be complementary to the answer(s) when they come along.)
It seems that, in order to make meaningful statistical statements, one needs densities/likelihood functions. Therefore a dominating measure necessarily shows up somewhere in the formulation, even in the non-parametric setting.
For example, take the classical fixed design non-parametric regression problem
$$
y_t = f(t) + \epsilon_t, \;\;t = \frac{k}{n}, \; k = 0, \cdots, 1,
$$
where $\epsilon_t \stackrel{i.i.d.}{\sim} (0, \sigma^2)$, and $f$ lies in, say, $C[0,1]$, the continuous functions on $[0,1]$.
The problem of estimating $f$ from $(y_t)$ is asymptotically equivalent to estimating drift $f$ from a sample path $Y_t$ of the stochastic process (Ito diffusion)
$$
dY_t = f dt + \sigma dW_t
$$
where $W_t$ is standard Brownian motion.
In this formulation, the problem becomes estimating a element $f$ of an infinite dimensional "parameter space" $C[0,1]$.
Statistically speaking, $Y_t$ is a probability measure $\mathbb{Q}^f$ on the Skorohod space $D[0,1]$, with Radon-Nikodym density
$$
\frac{d \mathbb{Q}^f}{ d \mathbb{P}} =e^{\int_0^1 \frac{f}{\sigma} dW_t - \frac{1}{2} \int_0^1 \frac{f^2}{\sigma^2} dt}
$$
with respect to the Wiener measure $\mathbb{P}$, which defines the law of $W$ (i.e. $f = 0$).
This is exactly like the parametric setting, except the model $\{ \mathbb{Q}^f \}_{ f \in C[0,1] }$ has an infinite dimensional "parameter space".
I believe the notion of contiguity, introduced by Le Cam, is in similar spirit---to introduce a framework where one can speak about densities and likelihood functions, when the parameter space is not necessarily finite-dimensional.