Assume, one deals with polynomial regression, i.e. $$ y_{i} = \beta_{0} + \beta_{1}x_{i} + \beta_{2}x_{i}^{2}+ \dots + \beta_{m}x_{i}^{m} + \varepsilon_{i}, $$ where $i = 1, \dots, n$, with $m < n$. Then, the OLS solution is given by $$ \hat{\beta} = (X^{T}X)^{-1}X^{T}y $$
The matrix $X$ is Vandermonde. Assume that all $x_{i}$ are distinct. In this case solution exists, but, because of bad invertibility of Vandermond matrix, the solution is not "stable". Therefore, the point estimation of covariance matrix of coefficients $\beta$ will not be trustable.
The question: will a bootstrap be better approach to estimate the variance of estimates of $\beta$, provided that the size of data set, $n$ is moderately large?
P.S. The question is not only about OLS for polynomial regression. It is more about using of sampling methods for (possible) improvements for the problems which suffer from computational instability.