The survival function $S_{t}$ is a quantity of interest in many (most?) kinds of event history analysis. It is commonly estimated, and 'survival curves' depicting $S_{t}$ versus time are often used to compare the cumulative probability of events among different groups. Statistical comparisons are often facilitated by inference—things like hypothesis test and confidence intervals.
I and a few statisticians have struggled with several different approaches to provide an asymptotic analytic estimator of the sample variance of the survival function ($\sigma^{2}_{\hat{S}_{t}}$) in discrete time event history models (a la logit hazard, probit hazard, etc. models), which would be useful to construct hypothesis tests and confidence intervals.
It turns out that—as best I understand it—that while it is possible and common to estimate the asymptotic variance of sums of random variables (like the sample mean), the asymptotic variance of products of random variables is a tricky sticky wicket to estimate.
$$\hat{S}_{t} = \prod^{t}_{i=1}{1-\hat{h}_{i}}$$
where $\hat{h}_{t}$ is the discrete time hazard function at time $t$.
We have more or less given up on an asymptotic estimator of the variance of that puppy, and declared that numerical techniques like bootstrapping seem to be our best bets.