Biology Stack Exchange
Biology Stack Exchange

Questions tagged [clinical-trial]

A clinical trial is the process in which new drugs are tested under controlled conditions.

New drugs are tested in controlled clinical trial. To be accepted by the medical regulation bodies, they have to fulfill certain criteria. First, the new drug is either tested against a placebo or against the current best treatment for a disease. Then, all participants including doctors and nurses are so called double-blinded, which means no participant knows who gets the new medication and who belongs to the control group.

16 questions
38
votes
7 answers

Has there even been a clinical study where healthy volunteers consented to be infected with a pathogen?

I am curious if there has ever been a (modern) clinical study where a healthy volunteer was purposefully infected with a pathogen in order to test the effectiveness of a therapeutic or preventative measure (like a vaccine)? If not, would the FDA…
Nova
  • 723
  • 1
  • 6
  • 13
20
votes
4 answers

Why have a placebo control group when testing a new drug if existing drugs can be used?

It is general practice to compare a new treatment against a sham treatment (placebo), and then use those results to compare efficacy of the new treatment (call it B) to an existing treatment (call it A), at least when existing treatments are…
Daniel Goldman
  • 321
  • 2
  • 10
8
votes
1 answer

Are there medical treatments that were so effective they were never subjected to a randomized control trial?

I'm thinking of things like antibiotics for meningitis or tuberculosis, or thiamine for Wernicke-Korsakoff syndrome. In those cases the magnitude of the treatment effect might have been so great that it would have been unethical to assign subjects…
user1205901 - Слава Україні
  • 756
  • 6
  • 13
7
votes
2 answers

Long-term efficacy and absence of side effects of anti-covid vaccines

The question is about the methodology/biostatistics of clinical trials (I state this beforehand to avoid accusations of being an anti-vaxxer). As multiple anti-COVID vaccines are offered on the market, the question naturally arises about their…
Roger Vadim
  • 3,802
  • 8
  • 26
5
votes
2 answers

What is overdiagnosis?

What is overdiagnosis ? I have searched this Wiki result but didn't understood at all. Can you please explain the first two line of Wikipedia : Overdiagnosis is the diagnosis of "disease" that will never cause symptoms or death during a patient's…
user 31466
  • 153
  • 3
5
votes
1 answer

Are there any online resources one can use to access raw clinical trial data without having to contact those involved in the study?

I want to do some statistical analysis and I have a preference for real data so I was wondering if there's somewhere I can get such data for free without a heap of bother in phoning those involved in the studies in question.
Josh Pinto
  • 2,398
  • 2
  • 17
  • 30
4
votes
1 answer

What is the difference between [Clinical Trials as Topic] category and [Clinical Trial [Publication Type]] category in pubmed?

Dears in biology stackexchange community, I hope that everyone is fine. I am using pubmed in my current review. My focus is about an application on the scope of Clinical Trial. When I used MeSH for narrowing my research scope on Clinical Trial, I…
medicalresearcher
  • 43
  • 3
4
votes
1 answer

Why are pharmacology studies so experimental?

I am a med student, and as far as I see from our pharmacology lectures, pharmacologists work almost completely experimental. Quite typically they take a substance (e.g., from nature), they add, change or remove some chemical groups, and then they…
user13196
2
votes
1 answer

Where can I find clinical trial data published in JAMA?

Data in the paper: http://jama.jamanetwork.com/article.aspx?articleid=336799 is cited in the statistical analysis in the book Clinical Trial Data Analysis using R. Can anyone help me find it?
TMOTTM
  • 583
  • 1
  • 5
  • 12
2
votes
0 answers

Source of journals collecting titles of scientific publications regarding clinical trials with dogs fed medicinal herbs

After some time researching on the web, you can find a lot of websites telling you that some herbs may have or have specific properties(unfortunately most seem to be "advertised" as if they were wonder drugs), but none or few give references to…
shooting-squirrel
  • 241
  • 2
  • 12
2
votes
1 answer

Any evidence that getting a covid booster works for omicron?

I've been hearing colloquially that the booster helps for immunity to Omicron, but haven't actually found any evidence supporting this. Does anyone know of any studies that look at the efficacy of the vaccine for Omicron cases?
Steven Sagona
  • 151
  • 7
1
vote
0 answers

What changes would allow cutting mRNA-based vaccine safety testing to 18 Months

I see a lot of skepticism among my fellow citizens following an interview that Bill Gates gave the BBC on the topic of Corona vaccines. The Gates foundation is funding several study ventures on Corona vaccines, conventional vaccines as well as…
akraf
  • 382
  • 2
  • 8
1
vote
0 answers

What disposition means in the context of registering clinical studies?

I was diving into the AACT database, and in the studies table I had noticed some columns containing the term disposition such as: disposition_first_submitted_date disposition_first_submitted_qc_date (qc means quality…
atevm
  • 299
  • 2
  • 7
1
vote
1 answer

What is a Archival Tumor Tissue ? For What Purpose is it collected?

Over the course of Conducting trials various tissue and tumor samples are collected from the patients. One such sample is the Archival Tumor Tissue. Could someone kindly clarify what is the meaning of the term archival tumor?, and what data is…
Vigneswara Prabhu
  • 129
  • 1
  • 6
1
vote
0 answers

Why aren't drugs tested on sick patients proactively?

I read an article about a new drug which may stop neurodegenerative activity in the brain and this triggered a question I had for some time already. Why such novel drugs are not tested on seriously/terminally ill patients, to check whether they are…
WoJ
  • 455
  • 1
  • 3
  • 10
1
2