The trimmed mean answer a different question than the mean: "What is a typical value for the distribution?". If you take the trimmed distribution, you explicitly state: I am not interested in outliers/ the tails of the distribution. If you belief that the "outliers" are really outliers (i.e., they do not belong to the distribution, but are of "another kind") then do trimming. If you think they belong to the distribution, but you want to have a less skewed distribution, you could think about winsorising.
Besides that, I would not recommend to enter a trimmed data set into a OLS regression. It would be better to use a robust regression technique right away, e.g.:
- Theil-Sen Regression
- Least trimmed squares
- Regression based on MM-estimators
All of these techniques can be computes with the WRS package in R
.
A good start for robust statistics is Wilcox's book.
Wilcox, R. R. (2010). Fundamentals of modern statistical methods: Substantially improving power and accuracy. Springer Verlag.